Pub. Date : 2000 Aug 1
PMID : 10897033
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Transformation of BALB3T3 cells caused by over-expression of rat CD98 heavy chain (HC) requires its association with light chain: mis-sense mutation in a cysteine residue of CD98HC eliminates its transforming activity. | Cysteine | solute carrier family 3 member 2 | Homo sapiens |
| 2 | In this study, we established and analyzed BALB3T3 clones transfected with cDNAs encoding wild-type and mutated rat CD98HC proteins designated as BrH/Wild, C103S, C325S and 103/325, in which 103 and/or 325 cysteine were intact or replaced with serine. | BR-HIBO | solute carrier family 3 member 2 | Homo sapiens |
| 3 | Immunoprecipitation with B3 revealed that exogenous rat CD98HC proteins were associated with endogenous mouse CD98LC by a disulfide bond in BrH/Wild and C325S, but not in C103S and 103/325 transfectants. | Disulfides | solute carrier family 3 member 2 | Homo sapiens |
| 4 | These findings indicate that over-expression of CD98HC and its disulfide-linkage with CD98LC at the cell surface result in malignant transformation of murine fibroblasts. | Disulfides | solute carrier family 3 member 2 | Homo sapiens |