Title : Human placenta sphingomyelinase, an exogenous acidic pH-optimum sphingomyelinase, induces oxidative stress, glutathione depletion, and apoptosis in rat hepatocytes.

Pub. Date : 2000 Jul

PMID : 10869289






1 Functional Relationships(s)
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1 Thus, these findings reveal the ability of ASMase to induce oxidative stress as a result of the targeting of mitochondria, and that GSH depletion sensitizes hepatocytes to the ASMase-induced apoptosis. Glutathione sphingomyelin phosphodiesterase 1 Homo sapiens