Pub. Date : 2000 Jul
PMID : 10854270
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. | Glutamic Acid | metallothionein 3 | Mus musculus |
| 2 | Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. | Nitric Oxide | metallothionein 3 | Mus musculus |
| 3 | Metallothionein (MT)-III, a member of the MT family of metal-binding proteins, is mainly expressed in the CNS and is abundant in glutamatergic neurons. | Metals | metallothionein 3 | Mus musculus |
| 4 | The aim of this work was to assess whether MT-III is able to prevent glutamate neurotoxicity and to identify the step of the neurotoxic process interfered with by MT-III. | Glutamic Acid | metallothionein 3 | Mus musculus |
| 5 | It is shown that MT-III prevented glutamate- and nitric oxide-induced neurotoxicity in a dose-dependent manner, with nearly complete protection at 0.3-1 microgram/ml. | Glutamic Acid | metallothionein 3 | Mus musculus |
| 6 | It is shown that MT-III prevented glutamate- and nitric oxide-induced neurotoxicity in a dose-dependent manner, with nearly complete protection at 0.3-1 microgram/ml. | Nitric Oxide | metallothionein 3 | Mus musculus |
| 7 | MT-III did not prevent the glutamate-induced rise of intracellular calcium level but reduced significantly the nitric oxide-induced formation of cyclic GMP. | Nitric Oxide | metallothionein 3 | Mus musculus |
| 8 | MT-III did not prevent the glutamate-induced rise of intracellular calcium level but reduced significantly the nitric oxide-induced formation of cyclic GMP. | Cyclic GMP | metallothionein 3 | Mus musculus |
| 9 | Circular dichroism analysis revealed that nitric oxide triggers the release of the metals coordinated to the cysteine residues of MT-III, indicative of the S(Cys)-nitrosylation of the protein. | Nitric Oxide | metallothionein 3 | Mus musculus |
| 10 | Circular dichroism analysis revealed that nitric oxide triggers the release of the metals coordinated to the cysteine residues of MT-III, indicative of the S(Cys)-nitrosylation of the protein. | Cysteine | metallothionein 3 | Mus musculus |
| 11 | Circular dichroism analysis revealed that nitric oxide triggers the release of the metals coordinated to the cysteine residues of MT-III, indicative of the S(Cys)-nitrosylation of the protein. | Cysteine | metallothionein 3 | Mus musculus |
| 12 | Therefore, the present results indicate that MT-III can quench pathological levels of nitric oxide, thus preventing glutamate and nitric oxide neurotoxicity. | Nitric Oxide | metallothionein 3 | Mus musculus |
| 13 | Therefore, the present results indicate that MT-III can quench pathological levels of nitric oxide, thus preventing glutamate and nitric oxide neurotoxicity. | Glutamic Acid | metallothionein 3 | Mus musculus |
| 14 | Therefore, the present results indicate that MT-III can quench pathological levels of nitric oxide, thus preventing glutamate and nitric oxide neurotoxicity. | Nitric Oxide | metallothionein 3 | Mus musculus |