Title : Synthesis of analogues of (-)-cytisine for in vivo studies of nicotinic receptors using positron emission tomography.

Pub. Date : 2000 Apr 20

PMID : 10804569






2 Functional Relationships(s)
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1 The protection of the amine with a nitroso group and the use of PdCl2(PPh3)2 to carry out the Stille reaction allowed the rapid synthesis of 9-(4"-[18F]fluorophenyl)cytisine (18F: t1/2 = 109.7 min), a new promising radioligand (radiochemical yield: 10% from [18F]KF, 150 min, four steps) for positron emission tomography studies of alpha 4 beta 2 nicotinic receptors. Amines phosducin like 2 Homo sapiens
2 The protection of the amine with a nitroso group and the use of PdCl2(PPh3)2 to carry out the Stille reaction allowed the rapid synthesis of 9-(4"-[18F]fluorophenyl)cytisine (18F: t1/2 = 109.7 min), a new promising radioligand (radiochemical yield: 10% from [18F]KF, 150 min, four steps) for positron emission tomography studies of alpha 4 beta 2 nicotinic receptors. 9-(4"-[18f]fluorophenyl)cytisine phosducin like 2 Homo sapiens