Pub. Date : 2000 Apr 13
PMID : 10803462
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The GTP-binding protein, R-Ras3/M-Ras, is a novel member of the Ras subfamily of GTPases which shows highest sequence similarity to the TC21 gene. | Guanosine Triphosphate | muscle RAS oncogene homolog | Homo sapiens |
| 2 | The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes. | Wortmannin | muscle RAS oncogene homolog | Homo sapiens |
| 3 | The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | muscle RAS oncogene homolog | Homo sapiens |
| 4 | The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | muscle RAS oncogene homolog | Homo sapiens |
| 5 | The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | muscle RAS oncogene homolog | Homo sapiens |
| 6 | The activation of Akt by R-Ras3 was most likely to be PI3-K-dependent since this biochemical event was blocked by the pharmacological inhibitors, Wortmannin and LY294002, as well as by a dominant negative mutant of PI3-K. More importantly, R-Ras3 affinity-precipitated PI3-K from cell extracts in a GTP-dependent manner, and associated lipid kinase activity was readily detectable in R-Ras3 immune complexes. | Guanosine Triphosphate | muscle RAS oncogene homolog | Homo sapiens |
| 7 | As expected, this biological activity of R-Ras3 was also abrogated by the addition of LY294002. | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one | muscle RAS oncogene homolog | Homo sapiens |