Title : Biochemical characterization of dichlorvos-induced delayed neurotoxicity in rat.

Pub. Date : 2000 Feb

PMID : 10776595






6 Functional Relationships(s)
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1 The Ki of dichlorvos for NTE was calculated to be 1.28 x 10(3) M-1 min-1. Dichlorvos patatin-like phospholipase domain containing 6 Rattus norvegicus
2 In vitro reactivation and ageing studies revealed that dichlorvos-inhibited NTE became refractory to activation by potassium fluoride after 5 min in the ageing medium, thus indicating the formation of an aged complex between dichlorvos and NTE. Dichlorvos patatin-like phospholipase domain containing 6 Rattus norvegicus
3 In vitro reactivation and ageing studies revealed that dichlorvos-inhibited NTE became refractory to activation by potassium fluoride after 5 min in the ageing medium, thus indicating the formation of an aged complex between dichlorvos and NTE. Dichlorvos patatin-like phospholipase domain containing 6 Rattus norvegicus
4 In vitro reactivation and ageing studies revealed that dichlorvos-inhibited NTE became refractory to activation by potassium fluoride after 5 min in the ageing medium, thus indicating the formation of an aged complex between dichlorvos and NTE. potassium fluoride patatin-like phospholipase domain containing 6 Rattus norvegicus
5 In vitro reactivation and ageing studies revealed that dichlorvos-inhibited NTE became refractory to activation by potassium fluoride after 5 min in the ageing medium, thus indicating the formation of an aged complex between dichlorvos and NTE. Dichlorvos patatin-like phospholipase domain containing 6 Rattus norvegicus
6 In vivo also, dichlorvos (200 mg/kg body wt) given as a single subcutaneous dose inhibited NTE in brain at various intervals after exposure (24 h, 10 days, and 21 days). Dichlorvos patatin-like phospholipase domain containing 6 Rattus norvegicus