Pub. Date : 2000 Mar
PMID : 10723089
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of a rel-A/CEBP-beta-related transcription factor heteromer by PGG-glucan in a murine monocytic cell line. | poly-1-6-glucopyranosyl-1-3-glucopyranose glucan | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 2 | Previously we reported that PGG-Glucan treatment of mouse BMC2.3 macrophage cells activates a nuclear factor kappa-B-like (NF-kappaB) transcription factor complex containing subunit p65 (rel-A) attached to an unidentified cohort. | poly-1-6-glucopyranosyl-1-3-glucopyranose glucan | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 3 | Previously we reported that PGG-Glucan treatment of mouse BMC2.3 macrophage cells activates a nuclear factor kappa-B-like (NF-kappaB) transcription factor complex containing subunit p65 (rel-A) attached to an unidentified cohort. | poly-1-6-glucopyranosyl-1-3-glucopyranose glucan | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |
| 4 | These data are consistent with a model whereby treatment of BMC2.3 cells with PGG-Glucan activates IkappaB-alpha via PKC and/or PTK pathways, permitting translocation of the rel-A/CEBP-beta heteromer complex to the nucleus and increases its DNA-binding affinity. | poly-1-6-glucopyranosyl-1-3-glucopyranose glucan | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | Mus musculus |