Title : Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: protection by triacetyloleandomycin.

Pub. Date : 2000 Feb 15

PMID : 10644054






2 Functional Relationships(s)
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1 Triacetyloleandomycin, a specific inhibitor of CYP3A, protected rats pretreated with ethanol along with isopentanol from acetaminophen hepatotoxicity. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus
2 In rats pretreated with ethanol plus isopentanol, CYP3A, measured immunohistochemically, was decreased by acetaminophen treatment. isopentyl alcohol cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus