Title : Effects of ginsenosides on bovine adrenal tyrosine hydroxylase.

Pub. Date : 1999 Jul

PMID : 10432216






10 Functional Relationships(s)
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1 Effects of ginsenosides on bovine adrenal tyrosine hydroxylase. Ginsenosides tyrosine hydroxylase Bos taurus
2 The present study was undertaken to investigate the effects of ginsenosides on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Ginsenosides tyrosine hydroxylase Bos taurus
3 The present study was undertaken to investigate the effects of ginsenosides on bovine adrenal tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis. Ginsenosides tyrosine hydroxylase Bos taurus
4 Ginsenoside-Rb1, Rc, Re and Rg, inhibited the TH activity by 51.5, 25.4, 31.3, 44.3 and 43.3%, respectively, at a concentration of 80 microg/ml. Ginsenosides RB transcriptional corepressor 1 Bos taurus
5 Ginsenoside-Rb1, Rc, Re and Rg, inhibited the TH activity by 51.5, 25.4, 31.3, 44.3 and 43.3%, respectively, at a concentration of 80 microg/ml. Ginsenosides tyrosine hydroxylase Bos taurus
6 Ginsenoside-Rb1, Rc, Re and Rg1 exhibited noncompetitive inhibition of TH activity with a substrate L-tyrosine. Ginsenosides RB transcriptional corepressor 1 Bos taurus
7 Ginsenoside-Rb1, Rc, Re and Rg1 exhibited noncompetitive inhibition of TH activity with a substrate L-tyrosine. Ginsenosides tyrosine hydroxylase Bos taurus
8 From these results, it is presumed that the effects of ginsenosides on TH activity observed in vitro might be also produced in vivo, and thereby the inhibitory effects of ginsenosides on TH activity may be partially responsible for the antidopaminergic action of ginsenosides by reducing the availability of dopamine at the presynaptic dopamine receptor in vivo. Ginsenosides tyrosine hydroxylase Bos taurus
9 From these results, it is presumed that the effects of ginsenosides on TH activity observed in vitro might be also produced in vivo, and thereby the inhibitory effects of ginsenosides on TH activity may be partially responsible for the antidopaminergic action of ginsenosides by reducing the availability of dopamine at the presynaptic dopamine receptor in vivo. Ginsenosides tyrosine hydroxylase Bos taurus
10 From these results, it is presumed that the effects of ginsenosides on TH activity observed in vitro might be also produced in vivo, and thereby the inhibitory effects of ginsenosides on TH activity may be partially responsible for the antidopaminergic action of ginsenosides by reducing the availability of dopamine at the presynaptic dopamine receptor in vivo. Ginsenosides tyrosine hydroxylase Bos taurus