Pub. Date : 1999 Apr
PMID : 10233845
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. | Reactive Oxygen Species | MpV17 mitochondrial inner membrane protein | Mus musculus |
| 2 | Glomerular overproduction of oxygen radicals in Mpv17 gene-inactivated mice causes podocyte foot process flattening and proteinuria: A model of steroid-resistant nephrosis sensitive to radical scavenger therapy. | Steroids | MpV17 mitochondrial inner membrane protein | Mus musculus |
| 3 | The development of glomerular disease in Mpv17-/- mice was inhibited by scavengers of oxygen radicals (dithiomethylurea) and lipid peroxidation (probucol), but not by steroid treatment. | Reactive Oxygen Species | MpV17 mitochondrial inner membrane protein | Mus musculus |
| 4 | The development of glomerular disease in Mpv17-/- mice was inhibited by scavengers of oxygen radicals (dithiomethylurea) and lipid peroxidation (probucol), but not by steroid treatment. | dithiomethylurea | MpV17 mitochondrial inner membrane protein | Mus musculus |
| 5 | Although the glomerular polyanion was greatly reduced in proteinuric Mpv17-/- mice, it was preserved by antioxidative therapy. | polyanions | MpV17 mitochondrial inner membrane protein | Mus musculus |
| 6 | These results indicate that the glomerular disease in Mpv17-/- mice qualifies as a model of steroid-resistant focal segmental glomerulosclerosis and that experimental therapies with scavengers of oxygen radicals and lipid peroxidation efficiently ameliorate glomerular damage. | Steroids | MpV17 mitochondrial inner membrane protein | Mus musculus |