Title : IGF-I in experimental daunorubicin-induced cardiomyopathy in rabbits.

Pub. Date : 1999 Mar

PMID : 10215105






7 Functional Relationships(s)
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1 IGF-I in experimental daunorubicin-induced cardiomyopathy in rabbits. Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
2 The occurrence of IGF-I was investigated in rabbits with experimentally daunorubicin-induced cardiomyopathy. Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
3 A significant increase in the IGF-I was found in the left heart ventricle in daunorubicin cardiomyopathy (152.9 +/- 10.0 ng/g vs 95.1 +/- 4.2 ng/g in the control group). Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
4 Furthermore, in skeletal muscle, the levels of IGF-I in the daunorubicin group (839.0 +/- 142.1 ng/g) were significantly higher in comparison with the control group (482.5 +/- 83.1 ng/g). Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
5 The level of IGF-I in the left ventricle in the daunorubicin group (but not in the control group) was significantly higher than that in the liver. Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
6 The increase in IGF-I concentrations in the left heart ventricle after the administration of daunorubicin may thus reflect possible autocrine/paracrine role of IGF-I in cardiomyopathy. Daunorubicin insulin-like growth factor I Oryctolagus cuniculus
7 The increase in IGF-I concentrations in the left heart ventricle after the administration of daunorubicin may thus reflect possible autocrine/paracrine role of IGF-I in cardiomyopathy. Daunorubicin insulin-like growth factor I Oryctolagus cuniculus