Pub. Date : 1999 Mar
PMID : 10215105
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | IGF-I in experimental daunorubicin-induced cardiomyopathy in rabbits. | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
2 | The occurrence of IGF-I was investigated in rabbits with experimentally daunorubicin-induced cardiomyopathy. | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
3 | A significant increase in the IGF-I was found in the left heart ventricle in daunorubicin cardiomyopathy (152.9 +/- 10.0 ng/g vs 95.1 +/- 4.2 ng/g in the control group). | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
4 | Furthermore, in skeletal muscle, the levels of IGF-I in the daunorubicin group (839.0 +/- 142.1 ng/g) were significantly higher in comparison with the control group (482.5 +/- 83.1 ng/g). | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
5 | The level of IGF-I in the left ventricle in the daunorubicin group (but not in the control group) was significantly higher than that in the liver. | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
6 | The increase in IGF-I concentrations in the left heart ventricle after the administration of daunorubicin may thus reflect possible autocrine/paracrine role of IGF-I in cardiomyopathy. | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |
7 | The increase in IGF-I concentrations in the left heart ventricle after the administration of daunorubicin may thus reflect possible autocrine/paracrine role of IGF-I in cardiomyopathy. | Daunorubicin | insulin-like growth factor I | Oryctolagus cuniculus |