Pub. Date : 1999 Feb
PMID : 10069459
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway. | Resveratrol | tumor protein p53 | Homo sapiens |
| 2 | Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. | Resveratrol | tumor protein p53 | Homo sapiens |
| 3 | Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. | Resveratrol | tumor protein p53 | Homo sapiens |
| 4 | Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. | Resveratrol | tumor protein p53 | Homo sapiens |
| 5 | Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. | Resveratrol | tumor protein p53 | Homo sapiens |
| 6 | Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. | Resveratrol | tumor protein p53 | Homo sapiens |
| 7 | Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53-/-) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. | Resveratrol | tumor protein p53 | Homo sapiens |
| 8 | These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis. | Resveratrol | tumor protein p53 | Homo sapiens |