Title : Inhibition of RNA polymerase II as a trigger for the p53 response.

Pub. Date : 1999 Jan 21

PMID : 9989808






1 Functional Relationships(s)
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1 Here we report on the correlation between inhibition of mRNA synthesis and the induction of p53, p21WAF1 and apoptosis in diploid human fibroblasts treated with either UV light, cisplatin or the RNA synthesis inhibitors actinomycin D, DRB, H7 and alpha-amanitin. Dactinomycin tumor protein p53 Homo sapiens