Title : Mutagenesis of the conserved residue Glu259 of Gsalpha demonstrates the importance of interactions between switches 2 and 3 for activation.

Pub. Date : 1999 Feb 19

PMID : 9988742






2 Functional Relationships(s)
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1 We previously reported that substitution of Arg258 within the switch 3 region of Gsalpha impaired activation and increased basal GDP release due to loss of an interaction between the helical and GTPase domains (Warner, D. R., Weng, G., Yu, S., Matalon, R., and Weinstein, L. S. (1998) J Biol. Guanosine Diphosphate GNAS complex locus Homo sapiens
2 Gsalpha-E259D and Gsalpha-E259A purified from Escherichia coli had normal rates of GDP release (as assessed by the rate GTPgammaS binding). Guanosine Diphosphate GNAS complex locus Homo sapiens