Title : Effect of hypertension and captopril treatment on the vasopressin in the rat median eminence and posterior lobe of the hypophysis. An immunohistochemical study.

Pub. Date : 1999 Jan

PMID : 9987649






3 Functional Relationships(s)
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1 Effect of hypertension and captopril treatment on the vasopressin in the rat median eminence and posterior lobe of the hypophysis. Captopril arginine vasopressin Rattus norvegicus
2 We have found that the rats showing the lowest level of vasopressin-ir, in both ME and PL, were those from the SHR group, the concentration increasing after oral captopril treatment (SHR-T), although without reaching the values of WKY rats. Captopril arginine vasopressin Rattus norvegicus
3 Then, ACE inhibition by captopril influences vasopressin content in brain areas where the hormone is concentrated before being released, which supports the hypothesis that suggests a central modulatory effect of ACE inhibitors, contributing to their therapeutic action on hypertension. Captopril arginine vasopressin Rattus norvegicus