Title : Chemotherapy augments TRAIL-induced apoptosis in breast cell lines.

Pub. Date : 1999 Feb 1

PMID : 9973225






2 Functional Relationships(s)
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1 This was evidenced by the fact that chemotherapy agents that synergized with TRAIL (e.g., doxorubicin) themselves caused cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP), and their toxicity was blocked by the caspase inhibitor Z-Val-Ala-Asp(OMe)-CH2 (ZVAD-fmk). Doxorubicin caspase 3 Homo sapiens
2 The combination of TRAIL and doxorubicin caused significantly greater caspase-3 and PARP cleavage, and the combined toxicity also was inhibited by ZVAD-fmk. Doxorubicin caspase 3 Homo sapiens