Pub. Date : 1999 Feb 1
PMID : 9973225
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | This was evidenced by the fact that chemotherapy agents that synergized with TRAIL (e.g., doxorubicin) themselves caused cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP), and their toxicity was blocked by the caspase inhibitor Z-Val-Ala-Asp(OMe)-CH2 (ZVAD-fmk). | Doxorubicin | caspase 3 | Homo sapiens |
2 | The combination of TRAIL and doxorubicin caused significantly greater caspase-3 and PARP cleavage, and the combined toxicity also was inhibited by ZVAD-fmk. | Doxorubicin | caspase 3 | Homo sapiens |