Title : Molecular modeling of the major adduct of (+)-anti-B[a]PDE (N2-dG) in the eight conformations and the five DNA sequences most relevant to base substitution mutagenesis.

Pub. Date : 1999 Jan

PMID : 9934854






1 Functional Relationships(s)
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1 The potent mutagen/carcinogen 7R,8S-dihydroxy-9S, 10R-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene [(+)-anti-B[a]PDE], which is the activated form of benzo[a]pyrene (B[a]P), is able to induce different kinds of mutations (G-->T, G-->A, etc.). 7,8,9,10-tetrahydrobenzo(a)pyrene aldehyde dehydrogenase 7 family member A1 Homo sapiens