Title : A malignant transformation of human cells by 2,3,7,8-tetrachlorodibenzo-p-dioxin exhibits altered expressions of growth regulatory factors.

Pub. Date : 1999 Jan

PMID : 9934844






2 Functional Relationships(s)
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1 Whereas parental cells showed a dose-dependent increase of PAI-2 mRNA levels following TCDD exposure, the transformed cells did not show any significant induction. Polychlorinated Dibenzodioxins serpin family B member 2 Homo sapiens
2 Whereas plenty of studies demonstrated a number of immediate toxic effects by TCDD, this study revealed an initial evidence that altered expression of growth regulatory genes, such as PAI-2, TGF-beta1 or TNF-alpha, are some of the genetic events fixed in the genome following the successive cell divisions of TCDD-damaged cells. Polychlorinated Dibenzodioxins serpin family B member 2 Homo sapiens