Title : Altered expression of bone sialoproteins in vitamin D-deficient rBSP2.7Luc transgenic mice.

Pub. Date : 1999 Feb

PMID : 9933476






2 Functional Relationships(s)
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1 In situ hybridization using mouse cRNA probes revealed that the increased BSP expression and decreased OPN expression in the vitamin D3-deficient mice was primarily in osteoblastic cells on the surface of calvariae and endosteal spaces of alveolar bone, on newly formed epiphyseal bone, and in cementoblasts and in hypertrophic chondrocytes. Cholecalciferol secreted phosphoprotein 1 Mus musculus
2 These studies are the first to show that BSP and OPN are differentially regulated by vitamin D3 in vivo, reflecting the diverse roles of these protein in bone remodeling. Cholecalciferol secreted phosphoprotein 1 Mus musculus