Title : Inhibition of human smooth muscle cell proliferation in culture by farnesyl pyrophosphate analogues, inhibitors of in vitro protein: farnesyl transferase.

Pub. Date : 1999 Feb 15

PMID : 9933024






2 Functional Relationships(s)
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1 Several farnesyl pyrophosphate (FPP) analogues were synthesized and tested in vitro for their specificity in inhibiting squalene synthase (SS), PFT, or protein:geranylgeranyl transferase-1 (PGGT-1) activities (the latter was determined using a newly designed assay). farnesyl pyrophosphate farnesyl-diphosphate farnesyltransferase 1 Homo sapiens
2 Several farnesyl pyrophosphate (FPP) analogues were synthesized and tested in vitro for their specificity in inhibiting squalene synthase (SS), PFT, or protein:geranylgeranyl transferase-1 (PGGT-1) activities (the latter was determined using a newly designed assay). farnesyl pyrophosphate farnesyl-diphosphate farnesyltransferase 1 Homo sapiens