Title : Requirement for phosphatidylinositol-3'-kinase in cytokine-mediated germ cell survival during fetal oogenesis in the mouse.

Pub. Date : 1999 Feb

PMID : 9927327






1 Functional Relationships(s)
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1 Lastly, the antiapoptotic effects of SCF/LIF or IGF-I were almost entirely eliminated by cotreatment of fetal ovaries with either one of two inhibitors of phosphatidylinositol-3"-kinase (PI3K), LY294002 (5 microM) or wortmannin (50 nM), whereas cotreatment with an inhibitor of p70 S6 kinase (rapamycin, 25 ng/ml) was without effect. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one insulin-like growth factor 1 Mus musculus