Title : Leukotriene C4 is a tight-binding inhibitor of microsomal glutathione transferase-1. Effects of leukotriene pathway modifiers.

Pub. Date : 1999 Jan 22

PMID : 9890956






4 Functional Relationships(s)
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1 Here we report that leukotriene C4 is a potent inhibitor of MGST-1. Leukotriene C4 microsomal glutathione S-transferase 1 Homo sapiens
2 Leukotriene C4 analogues, which have been developed as antagonists of leukotriene receptors, were found to display varying degrees of inhibition of MGST-1. Leukotriene C4 microsomal glutathione S-transferase 1 Homo sapiens
3 Our discovery that leukotriene C4 and drugs developed based on its structure are potent inhibitors of MGST-1 raises the possibility that MGST-1 influences the cellular processing of leukotrienes. Leukotriene C4 microsomal glutathione S-transferase 1 Homo sapiens
4 Our discovery that leukotriene C4 and drugs developed based on its structure are potent inhibitors of MGST-1 raises the possibility that MGST-1 influences the cellular processing of leukotrienes. Leukotriene C4 microsomal glutathione S-transferase 1 Homo sapiens