Pub. Date : 1999 Jan
PMID : 9884322
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of human aldehyde dehydrogenase 1 by the 4-hydroxycyclophosphamide degradation product acrolein. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | In human liver cytosol incubations, HCY inhibited ALDH activity mainly through its degradation product acrolein, whereas carboxyethylphosphoramide mustard inhibited ALDH activity only at supraclinical concentrations. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | The inhibition of ALDH1 activity by acrolein in incubations with human erythrocyte ALDH1 was competitive with a Ki of 0.646 microM. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 4 | The inhibition of ALDH1 activity by acrolein in incubations with human erythrocyte ALDH1 was competitive with a Ki of 0.646 microM. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 5 | The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 6 | The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 7 | The percentage of inhibition of ALDH1 activity in vivo by acrolein in patients receiving CY was calculated based on the in vitro Ki of acrolein, the in vitro Km of HCY, and the in vivo peak blood concentrations of HCY and acrolein. | Acrolein | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |