Title : Binding of HMG-I(Y) elicits structural changes in a silencer of the human beta-globin gene.

Pub. Date : 1999 Jan

PMID : 9883803






2 Functional Relationships(s)
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1 In this study, we cloned two cDNAs encoding proteins which bind to an oligonucleotide in silencer I containing a BP1 binding site. Oligonucleotides BP1 Homo sapiens
2 HMG-I(Y) also binds to a second oligonucleotide containing a BP1 binding site located in a negative control region upstream of the delta-globin gene, suggesting a role for HMG-I(Y) in repression of adult globin genes. Oligonucleotides BP1 Homo sapiens