Title : Induction of apoptosis in breast cancer cells by TPA.

Pub. Date : 1998 Dec 3

PMID : 9879997






2 Functional Relationships(s)
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1 We found up-regulation of p21WAF1 and Bax expressions, however, the expressions of p53 and Bcl-2 genes remained unchanged in TPA-treated cells. Tetradecanoylphorbol Acetate BCL2 associated X, apoptosis regulator Homo sapiens
2 TPA-induced apoptosis appears to be mediated through a p53-independent pathway, and the up-regulation of p21WAF1 and Bax may be the molecular mechanisms by which TPA induces apoptosis. Tetradecanoylphorbol Acetate BCL2 associated X, apoptosis regulator Homo sapiens