Title : Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization.

Pub. Date : 1998 Dec

PMID : 9877018






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Resistance of neuronal nitric oxide synthase-deficient mice to cocaine-induced locomotor sensitization. Cocaine nitric oxide synthase 1, neuronal Mus musculus
2 The present study was undertaken to investigate whether mice lacking the neuronal nitric oxide synthase (nNOS) gene are protected from cocaine-induced behavioral sensitization. Cocaine nitric oxide synthase 1, neuronal Mus musculus
3 The present study was undertaken to investigate whether mice lacking the neuronal nitric oxide synthase (nNOS) gene are protected from cocaine-induced behavioral sensitization. Cocaine nitric oxide synthase 1, neuronal Mus musculus
4 Male homozygote nNOS(-/-) mice were sensitive to the acute effect of cocaine (15 mg/kg) on day 1; however, they developed neither a sensitized response to cocaine (on day 5 and 15) nor a conditioned locomotion. Cocaine nitric oxide synthase 1, neuronal Mus musculus
5 Taken together, our results suggest that the resistance of homozygote nNOS(-/-) mice to cocaine-induced behavioral sensitization is primarily due to the deletion of the nNOS gene. Cocaine nitric oxide synthase 1, neuronal Mus musculus
6 Taken together, our results suggest that the resistance of homozygote nNOS(-/-) mice to cocaine-induced behavioral sensitization is primarily due to the deletion of the nNOS gene. Cocaine nitric oxide synthase 1, neuronal Mus musculus