Title : The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin.

Pub. Date : 1998 Dec 14

PMID : 9875290






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The C-terminal domain of p53 catalyzes DNA-renaturation and strand exchange toward annealing between intact ssDNAs and toward eliminating damaged ssDNA from duplex formation through preferential recognition of damaged DNA by a duocarmycin. duocarmycin tumor protein p53 Homo sapiens
2 We found that DU-86, a duocarmycin derivative which alkylates DNA, bound ssDNA and enhanced the DNA binding activity of the p53 C-terminus. duocarmycin tumor protein p53 Homo sapiens