Pub. Date : 1999 Jan
PMID : 9869656
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 2 | Chinese hamster ovary cells overexpressing the oxysterol binding protein (OSBP) display enhanced synthesis of sphingomyelin in response to 25-hydroxycholesterol. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 3 | The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 4 | The role of oxysterol binding protein (OSBP), a high affinity receptor for 25-hydroxycholesterol, in activation of SM synthesis was assessed by overexpression in CHO-K1 cells. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 5 | When compared to mock transfected controls, three CHO-K1 clones overexpressing OSBP by 10- to 15-fold displayed a 2- to 3-fold enhancement of [3H]serine incorporation into sphingomyelin when treated with 25-hydroxycholesterol. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 6 | Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 7 | Closer examination of one of these clones (CHO-OSBP cells) revealed a >8.5-fold stimulation of sphingomyelin synthesis after a 6-h treatment with 25-hydroxycholesterol compared to 3.5-fold in controls, slightly higher basal levels of sphingomyelin synthesis, and a more rapid response to 25-hydroxycholesterol. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 8 | Results from overexpressing cells show that OSBP potentiates the stimulatory effects of 25-hydroxycholesterol on sphingomyelin synthesis. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |
| 9 | 25-Hydroxycholesterol promotes translocation of OSBP to the Golgi apparatus where it appears to stimulate conversion of ceramide to sphingomyelin. | 25-hydroxycholesterol | LOW QUALITY PROTEIN: oxysterol-binding protein 1 | Cricetulus griseus |