Title : A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent.

Pub. Date : 1998 Dec

PMID : 9865924






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1 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens
2 A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens
3 RH1, a water-soluble analogue of MeDZQ synthesized in this work, was a better substrate for recombinant human NQO1 than the parent compound. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens
4 In comparison to the parental cell line, RH1, MeDZQ, and mitomycin C were significantly more cytotoxic to BE-NQ7 cells (17-, 7-, and 3-fold, respectively), confirming that the presence of NQO1 is sufficient to increase cytotoxicity of these antitumor quinones. 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone NAD(P)H quinone dehydrogenase 1 Homo sapiens