Title : Inhibitory effect of rebamipide on the neutrophil adherence stimulated by conditioned media from Helicobacter pylori-infected gastric epithelial cells.

Pub. Date : 1999 Jan

PMID : 9862763






3 Functional Relationships(s)
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1 The increased production of IL-8 and expression of IL-8 mRNA were significantly inhibited by rebamipide (100-1000 microM) in a concentration-dependent manner. rebamipide C-X-C motif chemokine ligand 8 Homo sapiens
2 The increased production of IL-8 and expression of IL-8 mRNA were significantly inhibited by rebamipide (100-1000 microM) in a concentration-dependent manner. rebamipide C-X-C motif chemokine ligand 8 Homo sapiens
3 It is concluded that rebamipide exerts its preventive effect against H. pylori-evoked gastric mucosal cell inflammation by inhibition of the neutrophil adherence to the endothelial cells as well as by suppressing the surface expression of CD11b on neutrophils and the production of proinflammatory cytokine such as IL-8 from gastric epithelial cells. rebamipide C-X-C motif chemokine ligand 8 Homo sapiens