Pub. Date : 1998 Dec 18
PMID : 9856951
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The association of TCRzeta with CTLA-4, reconstituted in 293 transfectants, was enhanced by p56(lck)-induced tyrosine phosphorylation. | tcrzeta | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 2 | Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRzeta bound to CTLA-4 and abolished the p56(lck)-inducible TCRzeta-CTLA-4 interaction. | tcrzeta | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 3 | Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRzeta bound to CTLA-4 and abolished the p56(lck)-inducible TCRzeta-CTLA-4 interaction. | tcrzeta | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 4 | Coexpression of the CTLA-4-associated tyrosine phosphatase, SHP-2, resulted in dephosphorylation of TCRzeta bound to CTLA-4 and abolished the p56(lck)-inducible TCRzeta-CTLA-4 interaction. | tcrzeta | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |
| 5 | Thus, CTLA-4 inhibits TCR signal transduction by binding to TCRzeta and inhibiting tyrosine phosphorylation after T cell activation. | tcrzeta | cytotoxic T-lymphocyte associated protein 4 | Homo sapiens |