Pub. Date : 1998 Nov-Dec
PMID : 9855318
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alteration in indinavir clearance during interleukin-2 infusions in patients infected with the human immunodeficiency virus. | Indinavir | interleukin 2 | Homo sapiens |
| 2 | STUDY OBJECTIVE: To evaluate the effect of interleukin-2 (IL-2) infusions on the pharmacokinetics of indinavir in patients infected with the human immunodeficiency virus. | Indinavir | interleukin 2 | Homo sapiens |
| 3 | STUDY OBJECTIVE: To evaluate the effect of interleukin-2 (IL-2) infusions on the pharmacokinetics of indinavir in patients infected with the human immunodeficiency virus. | Indinavir | interleukin 2 | Homo sapiens |
| 4 | INTERVENTIONS: Observational study: trough indinavir concentrations were measured on day 1 and day 5 of IL-2 as part of a clinical trial. | Indinavir | interleukin 2 | Homo sapiens |
| 5 | MEASUREMENTS AND MAIN RESULTS: The area under the curve of indinavir increased in eight of nine patients by a mean of 88% (range -29-215%) between days 1 and 5 of IL-2 infusion. | Indinavir | interleukin 2 | Homo sapiens |
| 6 | Observational data in eight patients from the clinical trial showed significantly increased indinavir trough concentrations from 264+/-493 to 670+/-677 ng/ml in the presence of IL-2. | Indinavir | interleukin 2 | Homo sapiens |
| 7 | CONCLUSION: Indinavir concentrations were altered during IL-2 infusions, possibly by induction of IL-6. | Indinavir | interleukin 2 | Homo sapiens |