Title : Nuclear transport factor p10/NTF2 functions as a Ran-GDP dissociation inhibitor (Ran-GDI).

Pub. Date : 1998 Dec 3

PMID : 9843686






1 Functional Relationships(s)
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1 In this study, we show that mammalian p10/NTF2 dramatically inhibits the dissociation of [3H]GDP from Ran and the binding of [35S]GTPgammaS to Ran following the dissociation of non-radioactive GDP by RCC1, the only known mammalian guanine nucleotide exchange factor for Ran (Ran-GEF) [7]. Guanosine Diphosphate regulator of chromosome condensation 1 Homo sapiens