Title : Prevention of mammalian DNA reduplication, following the release from the mitotic spindle checkpoint, requires p53 protein, but not p53-mediated transcriptional activity.

Pub. Date : 1998 Nov 26

PMID : 9840938






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 To learn if transcriptional activation of downstream genes by p53 plays a role in this putative checkpoint, three cell lines were exposed to nocodazole. Nocodazole tumor protein p53 Homo sapiens
2 Incubation with nocodazole of cells containing wild-type p53 results in accumulation of both 2N and 4N populations of cells. Nocodazole tumor protein p53 Homo sapiens