Title : Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes. Characterization of novel anticoagulants.

Pub. Date : 1998 Dec 11

PMID : 9837939






12 Functional Relationships(s)
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Protein Name
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1 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
2 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
3 Heparin cofactor II is a naturally occurring anticoagulant that acts by specifically inhibiting thrombin and is facilitated by the binding of glycosaminoglycans such as heparin and dermatan sulfate. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
4 We have produced permanently activated heparin cofactor II molecules by covalent linkage to either heparin or dermatan sulfate. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
5 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes had catalytic antithrombin activities similar to those of the corresponding starting heparin and dermatan sulfate (86% and 110% of standard heparin and dermatan sulfate activity, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
6 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes had catalytic antithrombin activities similar to those of the corresponding starting heparin and dermatan sulfate (86% and 110% of standard heparin and dermatan sulfate activity, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
7 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes had catalytic antithrombin activities similar to those of the corresponding starting heparin and dermatan sulfate (86% and 110% of standard heparin and dermatan sulfate activity, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
8 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes had catalytic antithrombin activities similar to those of the corresponding starting heparin and dermatan sulfate (86% and 110% of standard heparin and dermatan sulfate activity, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
9 Covalent heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate complexes had catalytic antithrombin activities similar to those of the corresponding starting heparin and dermatan sulfate (86% and 110% of standard heparin and dermatan sulfate activity, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
10 Both heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate had fast bimolecular rate constants of 1.4 x 10(7) M-1 s-1 and 1.3 x 10(7) M-1 s-1, respectively, for reaction with thrombin. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
11 Both heparin cofactor II-heparin and heparin cofactor II-dermatan sulfate had fast bimolecular rate constants of 1.4 x 10(7) M-1 s-1 and 1.3 x 10(7) M-1 s-1, respectively, for reaction with thrombin. Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus
12 The intravenous half-life of the covalent complexes in rabbits was significantly longer than that of free heparin or dermatan sulfate (4.4, 3.4, 0.33, and 0.50 h for heparin cofactor II-heparin, heparin cofactor II-dermatan sulfate, heparin, and dermatan sulfate, respectively). Dermatan Sulfate heparin cofactor 2 Oryctolagus cuniculus