Title : Aversive effects of the C-fragment of Substance P in the dorsal periaqueductal gray matter.

Pub. Date : 1998 Nov

PMID : 9835395






4 Functional Relationships(s)
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1 Evidence from a previous study suggests an involvement of SP in the neural substrates of aversion in the dorsal periaqueductal gray matter (DPAG). dpag tachykinin precursor 1 Homo sapiens
2 The proaversive effects observed with DPAG microinjections of these neuropeptides in the present study gain further relevance when combined with previous reports showing unconditioned and conditioned aversive effects following DPAG microinjections of SP in the place aversion and the elevated plus maze tests, two widely used animal models of anxiety. dpag tachykinin precursor 1 Homo sapiens
3 The proaversive effects observed with DPAG microinjections of these neuropeptides in the present study gain further relevance when combined with previous reports showing unconditioned and conditioned aversive effects following DPAG microinjections of SP in the place aversion and the elevated plus maze tests, two widely used animal models of anxiety. dpag tachykinin precursor 1 Homo sapiens
4 These results confirm previous data showing that SP has a modulatory role in the DPAG and that its effects are probably due to its C-terminal fragment. dpag tachykinin precursor 1 Homo sapiens