Title : Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages.

Pub. Date : 1998 Dec 1

PMID : 9834096






1 Functional Relationships(s)
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1 We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for alpha2-macroglobulin, bradykinin, epidermal growth factor, and platelet-derived growth factor. Cyclosporine excision repaiross-complementing rodent repair deficiency, complementation group 8 Mus musculus