Title : Inhibition of voltage-dependent calcium channels by prostaglandin E2 in rat melanotrophs.

Pub. Date : 1998 Dec

PMID : 9832416






2 Functional Relationships(s)
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1 The inhibition by PGE2 was partially, but significantly, reduced by the selective EP1 antagonist, SC-51322. Dinoprostone prostaglandin E receptor 1 Rattus norvegicus
2 These results suggest that PGE2 inhibits P/Q- and L-type Ca2+ channels of rat melanotrophs via EP1 and EP3 receptors, which are coupled to pertussis toxin-sensitive G proteins, and produces both voltage-sensitive and -insensitive inhibition of Ca2+ channels. Dinoprostone prostaglandin E receptor 1 Rattus norvegicus