Title : A phase I study of high-dose tamoxifen for the treatment of refractory malignant gliomas of childhood.

Pub. Date : 1997 Jul

PMID : 9815790






1 Functional Relationships(s)
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1 The antiestrogen tamoxifen, a moderately potent PKC inhibitor, has been shown in vitro to block the proliferation of malignant glioma cell lines at concentrations several-fold higher than those typically attained during the treatment of breast cancer; such serum concentrations may be achieved with doses > 40 mg/m2 b.i.d. Tamoxifen proline rich transmembrane protein 2 Homo sapiens