Pub. Date : 1998 Nov 9
PMID : 9813145
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine unphosphorylated platelet SHP-1 is a substrate for calpain. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 2 | The platelet phosphotyrosine phosphatase (PTP) SHP-1 is tyrosine phosphorylated during thrombin-induced activation. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 3 | When SHP-1 was tyrosine phosphorylated by thrombin, further addition of A23187 failed to induce its cleavage. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 4 | In the presence of tyrphostin to inhibit thrombin-induced SHP-1 tyrosine phosphorylation, SHP-1 was cleaved. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 5 | In the presence of tyrphostin to inhibit thrombin-induced SHP-1 tyrosine phosphorylation, SHP-1 was cleaved. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 6 | Thus, only the tyrosine unphosphorylated form of SHP-1 was a substrate for calpain. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |
| 7 | The data show that SHP-1 is either tyrosine phosphorylated or cleaved by calpain, and suggest that SHP-1 cleavage does not contribute to A23187-induced PTP activity. | Tyrosine | protein tyrosine phosphatase non-receptor type 6 | Homo sapiens |