Title : Tumor necrosis factor induces ceramide oscillations and negatively controls sphingolipid synthases by caspases in apoptotic Kym-1 cells.

Pub. Date : 1998 Nov 20

PMID : 9813032






1 Functional Relationships(s)
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1 Distinct enzymes were found to contribute to three waves of ceramide, neutral sphingomyelinase, ceramide synthase, and acid sphingomyelinase, with peak activities at 1-2, 40, and around 200 min, respectively, the latter coinciding with progression to irreversible damage. Ceramides sphingomyelin phosphodiesterase 2 Homo sapiens