Pub. Date : 1998 Nov
PMID : 9808712
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tetraethylammonium (TEA) uptake by both MDCK-OCT1 and MDCK-OCT2 cells was markedly elevated when TEA was added to the basolateral medium, but not to the apical medium. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |
| 2 | Tetraethylammonium (TEA) uptake by both MDCK-OCT1 and MDCK-OCT2 cells was markedly elevated when TEA was added to the basolateral medium, but not to the apical medium. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |
| 3 | Tetraethylammonium (TEA) uptake by both MDCK-OCT1 and MDCK-OCT2 cells was markedly elevated when TEA was added to the basolateral medium, but not to the apical medium. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |
| 4 | Efflux of TEA from MDCK-OCT1 and MDCK-OCT2 cells was not changed by extracellular pH from 5.4 to 8.4, whereas TEA uptake by both transfectants was decreased by acidification of extracellular medium. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |
| 5 | Apparent Km values for TEA uptake by MDCK-OCT1 and MDCK-OCT2 cells were 38 and 45 microM, respectively. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |
| 6 | Although various hydrophilic organic cations such as 1-methyl-4-phenylpyridinium, cimetidine, quinidine, nicotine, N1-methylnicotinamide and guanidine markedly inhibited TEA uptake by both MDCK-OCT1 and MDCK-OCT2 cells, there were no significant differences in the apparent inhibition constants (Ki) against these organic cations between both transfectants. | Tetraethylammonium | solute carrier family 22 member 1 | Rattus norvegicus |