Title : Simultaneous binding of drugs with different chemical structures to Ca2+-calmodulin: crystallographic and spectroscopic studies.

Pub. Date : 1998 Nov 3

PMID : 9799490






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The data provide evidence that calmodulin can simultaneously accommodate trifluoperazine and KAR-2 as well as vinblastine and KAR-2, but not trifluoperazine and vinblastine. Vinblastine calmodulin 1 Homo sapiens
2 The combination of the binding and structural data suggests that distinct binding sites exist on calmodulin for vinblastine and KAR-2 which correspond, at least partly, to that of trifluoperazine at the C-terminal hydrophobic pocket and at an interdomain site, respectively. Vinblastine calmodulin 1 Homo sapiens