Title : A new preparation method for protein loaded poly(D, L-lactic-co-glycolic acid) microspheres and protein release mechanism study.

Pub. Date : 1998 Nov 13

PMID : 9795050






1 Functional Relationships(s)
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1 In vitro release experiments indicated that an initial lysozyme release rate from the microspheres was mainly controlled by ionic interaction between basic amino acid residues in lysozyme and free carboxylate groups in PLGA polymer chain ends, which was probed by incubating the microspheres in a series of media having different NaCl concentrations. Sodium Chloride lysozyme Homo sapiens