Title : Cisplatin and phorbol ester independently induce ERCC-1 protein in human ovarian carcinoma cells.

Pub. Date : 1998 Nov

PMID : 9772291






5 Functional Relationships(s)
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1 Cisplatin and phorbol ester independently induce ERCC-1 protein in human ovarian carcinoma cells. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
2 Enhanced ERCC-1 expression has been associated with clinical and cellular resistance to cisplatin. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
3 We therefore carried out this study to investigate the effect of cisplatin on ERCC-1 protein expression in A2780/CP70 human ovarian cancer cells. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
4 Western blot analysis showed that ERCC-1 protein levels were increased to more than 3 times control after a 1 h cisplatin exposure to A2780/CP70 cells in culture. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens
5 These results extend our previous observations that ERCC-1 mRNA expression is induced by cisplatin in this system. Cisplatin ERCC excision repair 1, endonuclease non-catalytic subunit Homo sapiens