Pub. Date : 1998 Nov
PMID : 9772291
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Cisplatin and phorbol ester independently induce ERCC-1 protein in human ovarian carcinoma cells. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
2 | Enhanced ERCC-1 expression has been associated with clinical and cellular resistance to cisplatin. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
3 | We therefore carried out this study to investigate the effect of cisplatin on ERCC-1 protein expression in A2780/CP70 human ovarian cancer cells. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
4 | Western blot analysis showed that ERCC-1 protein levels were increased to more than 3 times control after a 1 h cisplatin exposure to A2780/CP70 cells in culture. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |
5 | These results extend our previous observations that ERCC-1 mRNA expression is induced by cisplatin in this system. | Cisplatin | ERCC excision repair 1, endonuclease non-catalytic subunit | Homo sapiens |