Title : Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2.

Pub. Date : 1998 Sep

PMID : 9767597






4 Functional Relationships(s)
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1 Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export. 4-Nitroquinoline-1-oxide ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C
2 Epistasis analysis demonstrated that 4-NQO resistances mediated by the YRR1 and YRR1-1 alleles require the presence of the SNQ2 gene that encodes a multidrug resistance ATP binding cassette superfamily protein responsible for 4-NQO export. 4-Nitroquinoline-1-oxide ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C
3 These results establish that Yrr1p is important for 4-NQO resistance by mediating transcriptional activation of the SNQ2 gene in response to the stress imposed by 4-NQO. 4-Nitroquinoline-1-oxide ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C
4 These results establish that Yrr1p is important for 4-NQO resistance by mediating transcriptional activation of the SNQ2 gene in response to the stress imposed by 4-NQO. 4-Nitroquinoline-1-oxide ATP-binding cassette transporter SNQ2 Saccharomyces cerevisiae S288C