Title : Incorporation of extracellular phospholipids and their effect on the growth and lipid metabolism of the Saccharomyces cerevisiae cho1/pss mutant.

Pub. Date : 1998 Oct 2

PMID : 9767089






2 Functional Relationships(s)
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1 The cho1/pss mutant of Saccharomyces cerevisiae, which is auxotrophic for choline or ethanolamine because of the deficiency in phosphatidylserine synthesis, grew in the presence of 0.05 mM phosphatidylcholine (PC) with octanoic acids (diC8PC) or decanoic acids (diC10PC), but not in the presence of PC with longer acyl residues. Choline CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C
2 Addition of 10 mM hemicholinium-3, a choline transport inhibitor, or disruption of the CTR gene, which encodes a choline transporter, inhibited the growth of the cho1/pss mutant in the presence of choline, but not in the presence of 0.1 mM diC8PC. Choline CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C