Title : A role for polysialic acid in neural cell adhesion molecule heterophilic binding to proteoglycans.

Pub. Date : 1998 Oct 16

PMID : 9765230






3 Functional Relationships(s)
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1 A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region. Heparitin Sulfate neural cell adhesion molecule 1 Mus musculus
2 A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region. Heparitin Sulfate neural cell adhesion molecule 1 Mus musculus
3 A specific NCAM-heparan sulfate interaction in this adhesion was further indicated by its inhibition with monoclonal anti-NCAM Fab antibodies that recognize the known heparin-binding domain of NCAM and with the HBD-2 peptide derived from this region, but not with antibodies directed against other regions of the protein including the homophilic binding region. Heparitin Sulfate neural cell adhesion molecule 1 Mus musculus