Title : Valproate and carbamazepine comedication changes hepatic enzyme activities in sera of epileptic children.

Pub. Date : 1998 Aug 28

PMID : 9764730






3 Functional Relationships(s)
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1 This study compares alanine aminotransferase (ALT), aspartate aminotransferase (AST) and gamma-glutamyltransferase (GGT) activities in sera of children treated with VPA (n=42), or CBZ (n=36) taken as a monotherapy, with VPA + CBZ combined therapy (n=36). Valproic Acid solute carrier family 17 member 5 Homo sapiens
2 The mean catalytic activity of AST was significantly elevated in groups on VPA, CBZ and VPA + CBZ treatment (2.02-, 1.49- and 1.45-fold increase, respectively) as compared to the control values. Valproic Acid solute carrier family 17 member 5 Homo sapiens
3 The mean catalytic activity of AST was significantly elevated in groups on VPA, CBZ and VPA + CBZ treatment (2.02-, 1.49- and 1.45-fold increase, respectively) as compared to the control values. Valproic Acid solute carrier family 17 member 5 Homo sapiens