Title : Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase.

Pub. Date : 1998

PMID : 9762350






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 DT-Diaphorase does not cause the production of an aerobic/hypoxic differential toxicity by mitomycin C, but rather activates this agent through an oxygen insensitive pathway. Oxygen NAD(P)H quinone dehydrogenase 1 Homo sapiens